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Abstract:
In a double-blind investigation the effect of oral controlled-release morphine (MST 30 mg) on pre-operative anxiety was assessed in 50 patients undergoing cholecystectomy. The effects on anaesthetic requirements and recovery, and postoperative pain were also studied. The patients who received morphine treatment were more sedated than those who received the placebo; however there was no significant difference in the anxiety scores for both groups of patients. During anaesthesia there were no significant differences between the groups, although the group of patients who received morphine required less anaesthetic supplement, and appeared to recover more slowly than the placebo group. One hour postoperatively, the morphine group had significantly less pain and were more sedated than the placebo group; the time to the administration of a postoperative analgesic was also significantly longer in the morphine group than the placebo group.
Insights
Controlled-release morphine (MST) did not reduce pre-operative anxiety but did decrease postoperative pain and sedation in patients undergoing cholecystectomy. Further research into MST
Area of Science:
- Anesthesiology
- Pharmacology
- Surgical Care
Background:
- Pre-operative anxiety is a common concern in surgical patients.
- Effective pain management post-cholecystectomy is crucial for recovery.
Purpose of the Study:
- To evaluate the efficacy of controlled-release morphine (MST 30 mg) in managing pre-operative anxiety.
- To assess the impact of MST on anesthetic requirements, recovery, and postoperative pain.
Main Methods:
- Double-blind investigation involving 50 patients undergoing cholecystectomy.
- Comparison between oral controlled-release morphine (MST 30 mg) and placebo.
- Assessment of anxiety, sedation, anesthetic needs, recovery time, and postoperative pain.
Main Results:
- Patients receiving MST showed increased sedation but no significant reduction in pre-operative anxiety.
- No significant differences in anesthetic requirements during surgery were noted, though less supplemental anesthetic was needed in the MST group.
- The MST group experienced significantly less postoperative pain and required analgesics later than the placebo group.
Conclusions:
- Oral controlled-release morphine (MST) effectively reduces postoperative pain and increases sedation after cholecystectomy.
- MST does not significantly alleviate pre-operative anxiety in this patient population.
- Further investigation is warranted regarding the prolonged recovery observed in the MST group.