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Related Experiment Videos

Human insulin allergy.

P Small, S Lerman

    Annals of Allergy
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Patients allergic to animal-derived insulin may react to human insulin. Allergy testing confirmed a severe reaction to human insulin (Humulin) in one such patient, indicating potential cross-reactivity.

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    Area of Science:

    • Immunology
    • Endocrinology
    • Dermatology

    Background:

    • Allergic reactions to insulin can occur, necessitating careful patient management.
    • Heterologous insulin, derived from non-human sources, has historically been associated with allergic responses.

    Observation:

    • A 70-year-old female experienced a generalized allergic reaction after receiving heterologous insulin.
    • Subsequent allergy testing involved epicutaneous application of human insulin (Humulin).

    Findings:

    • The patient exhibited a significant wheal and flare reaction upon testing with human insulin.
    • Generalized pruritus was also reported, confirming an allergic response to human insulin.

    Implications:

    • This case highlights the potential for allergic reactions to human insulin in patients previously sensitized to heterologous insulin.
  • Clinicians should consider the risk of cross-reactivity when switching insulin types for allergic patients.