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[Resistance to antibiotics of Proteus strains from various sources]
Abstract:
To show the distribution level of antibiotic resistant strains of Proteus and determine the identity of the strains of different origin, i.e. those isolated from humans, animals and environment, the sensitivity of 1084 strains of P. mirabilis and P. vulgaris to chloramphenicol, streptomycin, monomycin, ampicillin, kanamycin, gentamicin and rondomycin was studied with the method of serial dilutions in agar. 964 of them belonged to 28 O-antigen serogroups. Comparative analysis of the data showed that the strains resistant to the above antibiotics were present in all the Proteus groups studied. However, their frequency was different and depended on the antibiotic type and the serological group and origin of the strain. All the strains were resistant to chloramphenicol, while the number of the strains resistant to gentamicin was minimum and did not depend on their origin. The frequency of the rondomycin resistant strains among the isolates from the environment of the agricultural farms was significantly lower. The frequency of the strains resistant to kanamycin, streptomycin and monomycin was significantly higher among the isolates from humans. The difference in the Proteus strains of serogroups 03 and 041, as well as the other serogroups by the detection frequency and resistance to some antibiotics and the portion of the strains of the 4 resistant types or spectra was shown to be significant.
Insights
Antibiotic resistance varies in Proteus strains (P. mirabilis and P. vulgaris) from humans, animals, and the environment. Resistance patterns differ based on antibiotic type, serogroup, and origin, with all strains resistant to chloramphenicol.
Area of Science:
- Microbiology
- Antimicrobial Resistance
- Bacteriology
Background:
- Antibiotic resistance in Proteus species (Proteus mirabilis and Proteus vulgaris) is a growing public health concern.
- Understanding the distribution and characteristics of resistant strains across different origins is crucial for effective treatment and control.
Purpose of the Study:
- To investigate the prevalence of antibiotic resistance in Proteus strains isolated from human, animal, and environmental sources.
- To determine the identity and serogroup distribution of these antibiotic-resistant Proteus strains.
- To analyze the varying resistance patterns against a panel of common antibiotics.
Main Methods:
- Tested 1084 strains of P. mirabilis and P. vulgaris for sensitivity to chloramphenicol, streptomycin, monomycin, ampicillin, kanamycin, gentamicin, and rondomycin using serial dilutions in agar.
- Identified 964 strains belonging to 28 O-antigen serogroups.
- Performed comparative analysis of resistance frequencies based on strain origin and serogroup.
Main Results:
- All studied Proteus strains exhibited resistance to chloramphenicol.
- Gentamicin resistance was minimal and independent of strain origin.
- Significant variations in resistance frequencies were observed across different antibiotics, serogroups, and origins.
- Strains from humans showed higher resistance to kanamycin, streptomycin, and monomycin.
- Environmental isolates from agricultural farms had a significantly lower frequency of rondomycin resistance.
- Distinct differences in resistance patterns were noted between serogroups O3, O41, and other serogroups.
Conclusions:
- Antibiotic resistance is widespread in Proteus species, with varying distribution depending on the antibiotic, serogroup, and source.
- The origin of Proteus strains significantly influences their resistance profiles to specific antibiotics.
- These findings highlight the need for source-specific surveillance and targeted interventions to combat antibiotic resistance in Proteus.