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[Response to antibiotics of Proteus strains isolated from different types of clinical material]

P V Ovetchin, A Ia Tsyganenko

    Antibiotiki
    |April 1, 1984
    PubMed

    Insights

    Proteus strains show high resistance to common antibiotics like gentamicin, ampicillin, and carbenicillin. This widespread antibiotic resistance poses a significant challenge in clinical settings.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Antibiotic resistance in bacterial pathogens is a growing global health concern.
    • Proteus species are opportunistic pathogens frequently associated with hospital-acquired infections.

    Purpose of the Study:

    • To investigate the antibiotic susceptibility patterns of Proteus strains isolated from various clinical sources.
    • To determine the prevalence of resistance to gentamicin, ampicillin, and carbenicillin in Proteus mirabilis and Proteus vulgaris.

    Main Methods:

    • Isolation and identification of 42 Proteus strains from different hospital sources in Kharkov.
    • Antibiotic susceptibility testing using standard microbiological methods.
    • Determination of Minimum Inhibitory Concentrations (MIC) for carbenicillin.

    Main Results:

    • A high proportion of Proteus strains exhibited resistance to gentamicin (58.0-100%) and carbenicillin (66.6-100%) across different infection types.
    • Ampicillin resistance was also prevalent, particularly in Proteus vulgaris strains from otitis, urological diseases, and bronchopulmonary affections (66.6-100%).
    • Most strains showed MIC values for carbenicillin significantly above borderline, indicating substantial resistance.

    Conclusions:

    • The study highlights a significant level of antibiotic resistance in Proteus strains prevalent in Kharkov hospitals.
    • Resistance to gentamicin, ampicillin, and carbenicillin is widespread, irrespective of the isolation source.
    • These findings underscore the need for continuous monitoring of antibiotic resistance and the development of effective treatment strategies against Proteus infections.

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