Lack of effect of ibopamine, a dopamine pro-drug, on renal function in normal subjects

The effects of two single oral doses of ibopamine (150 and 600 mg) on heart rate, blood pressure, urine flow, sodium, potassium and creatinine excretion were studied in normal volunteers. No significant change was observed in urine flow, sodium, potassium or creatinine excretion at either dose. No significant change was observed in heart rate or blood pressure except that systolic blood pressure was transiently elevated after the 600 mg dose (P less than 0.05).