Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacokinetics and toxicity testing.

B Clark, D A Smith

    Critical Reviews in Toxicology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This study reviews drug absorption and clearance data in animals and humans to improve toxicity testing. It highlights pitfalls and proposes a rational approach for using pharmacokinetic data to assess new drug safety in humans.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Arboviruses in UK Armed Forces: a review of historical cases and identification of future threats.

    BMJ military health·2025
    Same author

    Is an Online Asynchronous Progressive Resistance Training Programme Feasible for Individuals With Down Syndrome?

    Journal of applied research in intellectual disabilities : JARID·2025
    Same author

    Animal health and welfare as a public good: what do the public think?

    Agriculture and human values·2024
    Same author

    State Leadership Academies to reduce cigarette smoking among people with behavioral health conditions in the United States.

    Preventive medicine reports·2024
    Same author

    Cross-disciplinary heat acclimatization research for climate change resilience.

    Journal of applied physiology (Bethesda, Md. : 1985)·2024
    Same author

    Interspecies encounters with endemic health conditions: co-producing BVD and lameness with cows and sheep in the north of England.

    Sociologia ruralis·2024
    Same journal

    Microplastic trafficking in maternal-fetal system: a systematic review and quantitative profiling linking particle characteristics to developmental biology.

    Critical reviews in toxicology·2026
    Same journal

    Addendum.

    Critical reviews in toxicology·2026
    Same journal

    Inhalation exposure and health effects of copper particles in the context of occupational exposure limit derivation.

    Critical reviews in toxicology·2026
    Same journal

    Screening for the ovarian toxicity of industrial chemicals - ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison.

    Critical reviews in toxicology·2026
    Same journal

    Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: input from an independent expert panel to support derivation of data-derived extrapolation factors.

    Critical reviews in toxicology·2026
    Same journal

    The effect of antioxidants on antineoplastic-induced male reproductive system damage: a systematic review of experimental studies.

    Critical reviews in toxicology·2026
    See all related articles

    Area of Science:

    • Pharmacokinetics
    • Drug Metabolism and Transport
    • Toxicology

    Background:

    • Toxicity testing relies on understanding drug absorption and clearance.
    • Existing data on drug pharmacokinetics in animals and humans provides a basis for comparison.
    • Empirical toxicology and misinterpretation of kinetic data present challenges.

    Purpose of the Study:

    • To discuss the pharmacokinetic basis for designing toxicity tests.
    • To review existing drug absorption and clearance data for comparative analysis.
    • To outline a rational approach for applying animal pharmacokinetic data to human safety assessment.

    Main Methods:

    • Review and examination of drug absorption and clearance data across species.
    • Identification of pitfalls in empirical toxicology and kinetic data interpretation.

    Related Experiment Videos

  • Development of a framework for rational application of pharmacokinetic data.

    • Main Results:

    • Established a comparative basis using existing pharmacokinetic data for new drug evaluation.
    • Highlighted common errors in toxicological assessments and data interpretation.
    • Proposed a structured method for extrapolating animal pharmacokinetic data to human safety.

    Conclusions:

    • Pharmacokinetic principles are crucial for effective toxicity testing design.
    • Rational application of animal pharmacokinetic data enhances the assessment of new therapeutic agent safety in humans.
    • Avoiding empirical pitfalls and correctly interpreting kinetic data is vital for drug safety evaluation.