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Chymopapain.

T R Einarson, J L Bootman, G H Smith

    Drug Intelligence & Clinical Pharmacy
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Chymopapain chemonucleolysis offers a 73% success rate for herniated lumbar disc treatment, providing a less invasive alternative to surgery. While side effects are rare, it effectively alleviates back pain and sciatica.

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    Area of Science:

    • Neurosurgery
    • Pain Management
    • Enzymology

    Background:

    • Herniated lumbar discs are a common cause of back pain and sciatica.
    • Conservative management options are sought to avoid surgical intervention.
    • Chymopapain is a proteolytic enzyme with potential therapeutic applications.

    Purpose of the Study:

    • To evaluate the safety and efficacy of chymopapain chemonucleolysis for treating herniated lumbar discs.
    • To compare outcomes of chymopapain treatment with surgical interventions.
    • To assess the role of chymopapain in conservative management strategies.

    Main Methods:

    • Intradiscal injection of chymopapain enzyme.
    • Assessment of pain elimination (backache and sciatica).
    • Monitoring of side effects, including anaphylaxis and post-treatment pain.

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    Main Results:

    • Achieved an average success rate of 73% in eliminating backache and sciatica.
    • Reported side effects in 3% of patients, with anaphylaxis in approximately 1%.
    • Patients experienced severe back pain or spasms in the first 24-48 hours post-treatment.

    Conclusions:

    • Chymopapain chemonucleolysis is a safe and effective treatment for herniated lumbar discs when performed by experienced physicians with adequate precautions.
    • This modality offers reduced hospital stays and faster return to work compared to surgery.
    • It can be considered a final conservative step before surgical intervention for lumbar disc herniation.