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Monensin toxicity in cattle.

E L Potter, R L VanDuyn, C O Cooley

    Journal of Animal Science
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Monensin toxicity in cattle is primarily a risk during initial feed exposure, with potential for mortality from mixing errors. However, cattle can recover from sublethal doses and show no reproductive harm.

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    Area of Science:

    • Veterinary Toxicology
    • Animal Science
    • Ruminant Nutrition

    Background:

    • Monensin is a widely used feed additive in cattle production.
    • Understanding its toxicity and safety profile is crucial for optimal animal husbandry.
    • Previous studies have indicated potential risks associated with high monensin concentrations.

    Purpose of the Study:

    • To comprehensively evaluate the toxicity and safety of monensin in cattle.
    • To identify the conditions and concentrations that pose the greatest risk of intoxication.
    • To assess the impact of monensin on cattle reproduction and long-term health.

    Main Methods:

    • Acute toxicity was assessed via single and 7-day oral gavage.
    • Feeding experiments utilized high concentrations of monensin in feed.

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  • Chronic studies included feedlot, pasture supplement, and reproduction trials.

    • Main Results:

    • Sublethal monensin doses caused temporary anorexia, with subsequent recovery of feed intake and growth.
    • High concentrations in feed led to mild intoxication signs and, in extreme cases, mortality.
    • No detrimental effects on reproduction were observed in chronic studies.
    • The highest risk of intoxication was identified during the initial introduction of monensin-containing feed.

    Conclusions:

    • Monensin toxicity in cattle is concentration-dependent and most critical during initial feed intake.
    • Careful feed mixing and adherence to recommended usage are essential to prevent mortality.
    • Monensin demonstrates a favorable safety profile regarding reproduction in cattle.