Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cell heterogeneity: evidence and implications.

K E Barrett, D D Metcalfe

    Journal of Clinical Immunology
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation.

    Biochemical and biophysical research communications·2022
    Same author

    Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.

    Allergy·2017
    Same author

    Proposed diagnostic criteria and classification of basophilic leukemias and related disorders.

    Leukemia·2017
    Same author

    Development and validation of the mastocytosis quality of life questionnaire: MC-QoL.

    Allergy·2016
    Same author

    Martin F. Kagnoff, MD: 1941-2014.

    Mucosal immunology·2015
    Same author

    KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis.

    Leukemia·2015

    Mast cells and basophils are key in allergies, but their normal functions remain unclear. Research shows mast cell characteristics vary significantly by tissue and species, impacting their roles.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Mast cells and basophils are central to allergic disease pathogenesis.
    • The physiological roles of these cells are not well understood.
    • Existing evidence suggests significant variability in mast cell properties.

    Purpose of the Study:

    • To review the evidence for mast cell heterogeneity.
    • To discuss the implications of this heterogeneity for understanding mast cell function.
    • To explore the clinical relevance of mast cell diversity.

    Main Methods:

    • Literature review of studies on mast cell properties.
    • Analysis of data on mast cell morphology, development, cytochemistry, and function.
    • Synthesis of findings regarding species and tissue-specific differences.

    Related Experiment Videos

    Main Results:

    • Mast cell properties are demonstrably dependent on the tissue and species of origin.
    • Heterogeneity is observed across multiple characteristics, including morphology, development, and function.
    • These variations have potential clinical implications for allergic diseases.

    Conclusions:

    • Mast cell heterogeneity is a significant factor in their biology.
    • Understanding these differences is crucial for elucidating their physiological roles.
    • Further research into mast cell diversity may lead to improved allergy treatments.