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Methenamine mandelate with acidification: an effective urinary antiseptic in patients with neurogenic bladder
Abstract:
We studied the effectiveness of methenamine mandelate in preventing urinary tract infection in patients with neurogenic bladder dysfunction who were in a program of intermittent catheterization and bladder retraining. Nine of 17 patients (53%) became infected while receiving the drug, whereas 19 of 22 patients (86%) in a placebo group became infected during the trial. The difference in infection rates was statistically significant (P less than 0.02) and resulted primarily from the absence of gram-positive cocci and Pseudomonas species in the drug group.
Insights
Methenamine mandelate significantly reduced urinary tract infections in patients with neurogenic bladder dysfunction undergoing intermittent catheterization. This treatment proved more effective than placebo, lowering infection rates and specific bacterial presence.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- Neurogenic bladder dysfunction frequently leads to recurrent urinary tract infections (UTIs).
- Patients with neurogenic bladders often require intermittent catheterization, increasing UTI risk.
- Effective UTI prophylaxis is crucial for managing neurogenic bladder complications.
Purpose of the Study:
- To evaluate the efficacy of methenamine mandelate in preventing UTIs.
- To assess its effectiveness in patients with neurogenic bladder dysfunction on intermittent catheterization.
- To compare infection rates between methenamine mandelate and placebo groups.
Main Methods:
- A clinical trial comparing methenamine mandelate to a placebo.
- Participants included patients with neurogenic bladder dysfunction undergoing intermittent catheterization and bladder retraining.
- Infection rates and causative bacterial species were monitored in both groups.
Main Results:
- Methenamine mandelate group: 9 of 17 patients (53%) experienced infections.
- Placebo group: 19 of 22 patients (86%) experienced infections.
- The reduction in infection rates with methenamine mandelate was statistically significant (P < 0.02), notably reducing gram-positive cocci and Pseudomonas infections.
Conclusions:
- Methenamine mandelate is effective in preventing UTIs in neurogenic bladder patients using intermittent catheterization.
- The drug demonstrated a significant decrease in infection rates compared to placebo.
- It showed particular efficacy against gram-positive cocci and Pseudomonas species.