Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cimetidine therapy does not prevent rebleeding from peptic ulceration.

D L Carr-Locke, D Taverner, A C Wicks

    Postgraduate Medical Journal
    |June 1, 1984
    PubMed
    Summary

    Cimetidine did not improve outcomes for patients with acute upper gastrointestinal bleeding from peptic ulcers. This study found no significant difference in transfusion needs, rebleeding, or surgery rates between cimetidine and placebo groups.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Experimental investigation of picosecond pulse reflection from fiber gratings.

    Optics letters·2009
    Same author

    Invited commentary. Carpal tunnel syndrome is one of the most common peripheral entrapment neuropathies and is associated with substantial direct medical costs and with economic costs in terms of man day loss and possible continuing disability.

    Neurology India·2009
    Same author

    Nonlinear switching in fibre Bragg gratings.

    Optics express·2009
    Same author

    Hypotension during ERCP is common but not a risk factor for post-ERCP pancreatitis.

    HPB : the official journal of the International Hepato Pancreato Biliary Association·2008
    Same author

    Experimental observation of nonlinear pulse compression in nonuniform Bragg gratings.

    Optics letters·2008
    Same author

    Highly efficient second-harmonic and sum-frequency generation of nanosecond pulses in a cascaded erbium-doped fiber:periodically poled lithium niobate source.

    Optics letters·2007

    Area of Science:

    • Gastroenterology
    • Clinical Pharmacology
    • Internal Medicine

    Background:

    • Acute upper gastrointestinal hemorrhage is a significant clinical concern.
    • Peptic ulceration is a common cause of upper GI bleeding.
    • Effective treatments are crucial for managing peptic ulcer bleeding.

    Purpose of the Study:

    • To evaluate the efficacy of cimetidine in treating acute upper gastrointestinal hemorrhage caused by peptic ulcers.
    • To compare cimetidine therapy with placebo in a prospective, double-blind, controlled trial.

    Main Methods:

    • A prospective, double-blind, controlled trial involving 105 patients with peptic ulceration-related upper GI bleeding.
    • Cimetidine or placebo therapy initiated within 12 hours of admission and continued for 7 days.

    Related Experiment Videos

  • Assessment of transfusion requirements, rebleeding rates, and surgical intervention.

    • Main Results:

    • Cimetidine therapy showed no significant difference compared to placebo in transfusion needs.
    • Rebleeding rates were similar between the cimetidine and placebo groups.
    • The number of operations performed did not differ between treatment groups for gastric or duodenal ulcers.

    Conclusions:

    • Cimetidine therapy provided no demonstrable benefit for patients with acute upper gastrointestinal hemorrhage due to peptic ulceration.
    • The drug was ineffective in reducing transfusion requirements, rebleeding, or the need for surgery.
    • No specific benefit was observed in elderly patients (over 65 years).