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[Primary pulmonary pseudolymphomas and lymphomas. 4 cases].

J F Cordier, J F Bernaudin, P Mary

    Revue Des Maladies Respiratoires
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Percutaneous Fine Needle Aspiration Cytology and Biopsy in the Diagnosis and Classification of Lymphoma: Clinical Evaluation.

    Leukemia & lymphoma·2016

    Primary pulmonary pseudolymphoma and lymphoma present similarly, often asymptomatic with subtle radiological findings. Distinguishing between benign and malignant lymphoid proliferation requires careful histological and immunological evaluation.

    Area of Science:

    • Pulmonary Medicine
    • Oncology
    • Immunology

    Background:

    • Primary pulmonary lymphoma and pseudolymphoma are rare lymphoid proliferations.
    • Distinguishing between these conditions pre-histologically is challenging.
    • Radiological findings are often nonspecific, showing opacities with soft contours and air bronchograms.

    Observation:

    • Four cases of primary pulmonary pseudolymphoma and lymphoma were analyzed.
    • Cases presented with asymptomatic radiological opacities and slow evolution.
    • Immunological studies (polyclonal vs. monoclonal lymphoid proliferation) were used to aid diagnosis.

    Findings:

    • One case of lymphoplasmacytic lymphoma showed monoclonal IgM gammopathy and IgM-positive cells.
    • Another case with pseudolymphoma histology had serum monoclonal gammopathy but no monoclonal markers on immunofluorescence.

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  • This suggests a spectrum from benign to malignant processes, potentially with coexistence or transition.

    • Implications:

    • The distinction between pseudolymphoma and lymphoma may not always be clear-cut.
    • Pulmonary lymphoproliferative disorders might represent a spectrum rather than distinct entities.
    • Further research into immunological markers is needed for accurate diagnosis and classification.