[Vaccination using Salmonella typhimurium Rc in protein-deprived BALB/c mice]

Four-week old BALB/c mice were fed a 4% protein diet for 6 weeks. At the 3rd week of undernourishment, they were orally vaccinated with a live vaccine, Salmonella typhimurium Rc. the mice were challenged 3 weeks after vaccination, and malnutrition was discontinued at that time. Results suggested that the live vaccine may be pathogenic when associated with a protein-deficient diet.