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Folate-dependent serine synthesis in lymphocytes from controls and patients with megaloblastic anaemia: the effect of
British Journal of Haematology
|March 1, 1978
Abstract:
The utilization of [14C]formate for serine synthesis by lymphocytes was impaired in all the patients with pernicious anaemia and in 70% of other patients with megaloblastic anaemia. In pernicious anaemia this was corrected by vitamin B12 therapy in 48 h but not by folate therapy although patients given folate showed a satisfactory haematological response.