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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

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Published on: March 22, 2012

Invasive pulmonary aspergillosis after near-drowning

D F Vieira, H K Van Saene, D R Miranda

    Intensive Care Medicine
    |January 1, 1984
    PubMed

    Insights

    A near-drowning patient developed severe acute respiratory distress syndrome (ARDS) and invasive pulmonary aspergillosis. Successful treatment with antifungal agents and supportive care led to full recovery and return to work.

    Area of Science:

    • Medicine
    • Pulmonology
    • Infectious Diseases

    Background:

    • Severe acute respiratory distress syndrome (ARDS) can arise after traumatic events like near-drowning.
    • Secondary fungal infections, such as invasive pulmonary aspergillosis, pose a significant risk in critically ill patients.

    Observation:

    • A 27-year-old male developed ARDS post-near-drowning.
    • Aspergillus fumigatus infection was confirmed with rising titers and lung cavities on imaging.
    • The patient required mechanical ventilation with PEEP and intensive care.

    Findings:

    • Combined treatment with Amphotericin B and 5-fluorocytosine, alongside mechanical ventilation and postural drainage, was effective.
    • Complete resolution of invasive pulmonary aspergillosis was achieved in 41 days.
    • The patient was discharged from the ICU and returned to his job six months later with normal clinical status.

    Implications:

    • This case highlights the potential for severe fungal superinfections in ARDS patients.
    • Aggressive antifungal therapy combined with intensive respiratory support can lead to favorable outcomes.
    • Early diagnosis and multidisciplinary management are crucial for treating invasive pulmonary aspergillosis in critically ill patients.

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