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A Rapid Automated Protocol for Muscle Fiber Population Analysis in Rat Muscle Cross Sections Using Myosin Heavy Chain Immunohistochemistry
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Transformation of fibre types in muscular dystrophies

G K Dhoot, G W Pearce

    Journal of the Neurological Sciences
    |July 1, 1984
    PubMed

    In the normal human skeletal muscle, slow and fast forms of troponin I are segregated in type I and type II cells, respectively. Muscle biopsies from different dystrophies showed a large number of intermediate cells that stained with antibodies to both fast and slow troponin I. Intermediate cells of variable size were scattered at random and did not show a motor unit distribution as generally seen in some neuromuscular disorders. The preponderance of a particular cell type depended on the type of dystrophy. Except for dystrophia myotonica, all cases showed presence of small cells that looked like regenerating cells.

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