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Motilin--an update.

J E Fox

    Life Sciences
    |August 13, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Motilin, a gastrointestinal hormone, may originate in the central nervous system (CNS) and influences neural transmission and gut motility. Its precise physiological role in the migrating motor complex (MMC) varies across species.

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    Area of Science:

    • Gastroenterology
    • Neuroendocrinology
    • Physiology

    Background:

    • Motilin, first isolated in 1971, was initially localized to gastrointestinal endocrine cells.
    • Recent evidence suggests a potential neural origin within the central nervous system (CNS).
    • Motilin influences neurotransmitter release in the CNS and motor activity in the gastrointestinal tract.

    Purpose of the Study:

    • To investigate the origin and physiological role of motilin.
    • To explore motilin's involvement in the migrating motor complex (MMC) across different species.
    • To correlate motilin release with gastrointestinal and secretory events.

    Main Methods:

    • Radioimmunoassay (RIA) and immunohistochemistry were used to determine motilin's origin.
    • Studies in various animal models (dog, pig) and humans were conducted.

    Related Experiment Videos

  • Observations correlated motilin levels with MMC activity and gastrointestinal secretions.

    • Main Results:

    • Motilin appears to have a CNS neural origin, influencing neural transmission and gut motility.
    • In fasting animals, motilin initiates premature MMC activity fronts via a sensitive mechanism.
    • Motilin's role in MMC generation is definitive in dogs, suggested in humans, and minimal in pigs.
    • Elevated motilin levels are associated with diarrhea, renal failure, and post-abdominal surgery states.

    Conclusions:

    • Motilin's exact physiological function remains under investigation in several species.
    • While implicated in MMC, its definitive role varies significantly across species.
    • Further research is needed to fully elucidate motilin's physiological and pathological significance.