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Heparin induced bleeding.

J Hirsh

    Nouvelle Revue Francaise D'Hematologie
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Heparin

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    Area of Science:

    • Pharmacology and Toxicology
    • Hematology
    • Thrombosis Research

    Background:

    • Heparin is a widely used anticoagulant.
    • Bleeding is a major side effect of therapeutic heparin administration.
    • Dissociating antithrombotic and hemorrhagic effects is a key research goal.

    Purpose of the Study:

    • To investigate the dissociation of heparin's antithrombotic and hemorrhagic effects.
    • To explore the role of platelet dysfunction in heparin-induced bleeding.
    • To evaluate novel heparin preparations and their clinical potential.

    Main Methods:

    • Review of existing evidence on heparin, low molecular weight heparins, and heparinoids.
    • Analysis of studies examining heparin's effect on platelet function.

    Related Experiment Videos

  • Assessment of the relationship between AT III affinity and anticoagulant/hemorrhagic effects.

    • Main Results:

    • Evidence suggests heparin's hemorrhagic effect may stem from reversible platelet dysfunction.
    • This platelet defect appears less critical for preventing experimental venous thrombosis than AT III-dependent anticoagulation.
    • Low molecular weight heparins, heparinoids, and low AT III affinity heparins show potential for dissociated effects.

    Conclusions:

    • Heparin's bleeding risk might be mitigated by targeting platelet function independently of anticoagulation.
    • Novel heparin derivatives offer promise for safer antithrombotic therapy.
    • Clinical trials are necessary to validate these findings in human thromboembolism disease.