Biokinetics and metabolism of radiogallium

The large number of publications dealing with biokinetics, metabolism and factors influencing tissue uptake of 67Ga-citrate could not clarify the mechanism responsible for the uptake of this compound into tumor tissue. The present paper reviews biokinetic data obtained from clinical investigations and animal experiments and briefly points out some possible pathways of the mechanism for gallium localisation in tumors as well as in abscesses and inflammatory lesions.