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Protein turnover with special reference to man.

J C Waterlow

    Quarterly Journal of Experimental Physiology (Cambridge, England)
    |July 1, 1984
    PubMed
    Summary
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    The end-product method of measuring whole-body protein turnover: a review of published results and a comparison with those obtained by leucine infusion.

    The British journal of nutrition·2005

    This review examines whole-body nitrogen flux and protein turnover in humans. It highlights how factors like body size, growth, metabolism, and intake influence protein dynamics, with implications for injury and exercise research.

    Area of Science:

    • Physiology
    • Biochemistry

    Background:

    • Protein turnover is crucial for physiological functions.
    • Understanding whole-body nitrogen flux is key to metabolic health.

    Purpose of the Study:

    • To review methods for measuring whole-body protein turnover.
    • To compare results from different measurement techniques, focusing on human studies.
    • To explore physiological aspects of protein turnover.

    Main Methods:

    • Review of existing literature on protein turnover measurement.
    • Comparative analysis of data from various whole-body protein turnover studies in humans.

    Main Results:

    • Protein turnover rates correlate with body size, growth, energy metabolism, and food intake.

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  • Significant increases in protein turnover are observed during injury.
  • Exercise-induced changes in protein turnover are an emerging area of research.

    • Conclusions:

    • Future research should focus on hormonal regulation of protein synthesis and breakdown.
    • Investigating the relationship between dynamic protein states, tissue structure, and function is essential.