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Dopamine antagonists in the upper gastrointestinal tract
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1984
Summary
Dopamine antagonists like metoclopramide and domperidone improve upper gastrointestinal motility by blocking dopamine's inhibitory effects. These drugs are valuable for treating gastroparesis, nausea, vomiting, and reflux esophagitis.
Area of Science:
- Pharmacology
- Gastroenterology
Background:
- Dopamine inhibits lower oesophageal sphincter pressure (LOSP) and gastroduodenal motility via specific receptors.
- Clinical use of dopamine antagonists is increasing due to their effects on upper GI tract motility.
Purpose of the Study:
- To investigate the effects of dopamine antagonists on upper gastrointestinal motility.
- To evaluate the therapeutic potential of dopamine antagonists in gastrointestinal disorders.
Main Methods:
- Administration of dopamine antagonists (metoclopramide, domperidone) alone and with dopamine.
- Assessment of changes in lower oesophageal sphincter pressure (LOSP) and gastroduodenal motility.
- Evaluation of gastric emptying rates.
Main Results:
- Dopamine antagonists counteract dopamine's inhibitory effects on LOSP and motility.
- When administered alone, these agents increase LOSP and stimulate gastroduodenal motility and gastric emptying.
Conclusions:
- Dopamine antagonists are effective in increasing upper GI motility.
- These drugs show therapeutic value in managing gastroparesis, nausea, vomiting, and reflux oesophagitis.