Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hemoglobinopathies in developing countries].

H R Marti

    Wiener Klinische Wochenschrift
    |July 6, 1984
    PubMed
    Summary
    This summary is machine-generated.

    New research reveals independent origins of the sickle mutation in Africa and Asia. Alpha-thalassaemia frequency is underestimated, and malaria resistance in haemoglobinopathies is better understood.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Frequency of Haemoglobin S and Glucose-6-Phosphate Dehydrogenase Deficiency in Southern Tanzania.

    British medical journal·2010
    Same author

    [50 years of Swiss Academy of Medical Sciences].

    Schweizerische medizinische Wochenschrift·1993
    Same author

    Automated blood count analysis by trimodal size distribution of leukocytes with the SYSMEX E-5000.

    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie·1989
    Same author

    [Hemoglobinopathies and erythrocyte enzyme deficiencies in Switzerland: laboratory diagnoses of the last 10 years].

    Schweizerische medizinische Wochenschrift·1987
    Same author

    Can automated haematology analysers discriminate thalassaemia from iron deficiency?

    Acta haematologica·1987
    Same author

    [Kala-azar imported from Yugoslavia].

    Schweizerische medizinische Wochenschrift·1986
    Same journal

    Systematic review of clinical evidence for Kneipp medicine.

    Wiener klinische Wochenschrift·2026
    Same journal

    Pelvic resections in primary sarcomas : Surgical outcomes and survival analysis of 75 patients.

    Wiener klinische Wochenschrift·2026
    Same journal

    Jungmediziner*innen am Start: 11. Workshop für den medizinischen Nachwuchs.

    Wiener klinische Wochenschrift·2026
    Same journal

    Stellungnahme der ÖGP zur geplanten Gesetzesnovelle zum Nichtraucherschutzgesetz.

    Wiener klinische Wochenschrift·2026
    Same journal

    MUW researcher of the month: Dr. Moritz Schaefer.

    Wiener klinische Wochenschrift·2026
    Same journal

    Alopecia areata: current concepts.

    Wiener klinische Wochenschrift·2026
    See all related articles

    Area of Science:

    • Hematology
    • Genetics
    • Molecular Biology

    Context:

    • Haemoglobinopathies are significant health issues in developing nations.
    • Modern research approaches are yielding new insights into these disorders.
    • Previous understanding of sickle mutation origins and thalassaemia prevalence was incomplete.

    Purpose:

    • To review key haemoglobinopathies in developing countries using updated research.
    • To investigate the independent origins of the sickle mutation.
    • To elucidate the genetic basis of Plasmodium falciparum resistance in sickle cell disorders and thalassaemia.

    Summary:

    • The sickle mutation arose independently in West Africa, distinct from East Africa and Asia. Alpha-thalassaemia prevalence is higher than previously thought in Mediterranean and African regions. Significant progress has been made in understanding the genetic resistance to malaria associated with sickle cell disorders and thalassaemia.

    Related Experiment Videos

  • Molecular investigations reveal the heterogeneity of alpha- and beta-thalassaemia at the globin gene level. Advances in clinical management, including blood transfusions and iron chelation, have improved life expectancy for thalassaemia major patients.
  • Developed countries have reduced haemoglobinopathy incidence through screening, education, genetic counseling, and prenatal diagnosis. However, these advanced strategies are not yet feasible for developing regions due to socioeconomic limitations.

    • Impact:

    • Enhanced understanding of the global distribution and genetic origins of sickle cell mutation and thalassaemia.
    • Improved insights into malaria resistance mechanisms linked to haemoglobinopathies.
    • Highlights the disparity in access to advanced diagnostic and management strategies between developed and developing countries.