Tolerability and usefulness of iohexol in cardioangiography. II. A double blind comparison with metrizoate

The new non-ionic contrast medium iohexol (Omnipaque) was compared with the ionic medium sodium meglumine calcium metrizoate (Isopaque Coronar) in a double blind, two-group trial. Iohexol resulted in significantly fewer and smaller subjective reactions than metrizoate. Changes of left ventricular and aortic pressure were statistically significantly less after injection of iohexol than of metrizoate. ECG recordings did not significantly differ in the two groups. Analysis of biochemical parameters showed no statistical differences between the two groups. Determination of serum enzyme activities revealed no signs of myocardial injury, and no impairment of glomerular filtration rate was detected by radionuclear renal function test. Similar radiographic quality was obtained with both media.