Iohexol in cerebral angiography. Survey and present state

Area of Science:

• Radiology
• Neuroradiology
• Medical Imaging

Background:

• Cerebral angiography requires contrast media for visualization.
• Ionic contrast media commonly cause patient discomfort (warmth, pain).
• Non-ionic contrast media aim to improve patient tolerance.

Purpose of the Study:

• To evaluate the safety and efficacy of iohexol in cerebral angiography.
• To compare patient-reported sensations with iohexol versus ionic contrast media.
• To assess the incidence of adverse reactions associated with iohexol.

Main Methods:

• Systematic review of 15 clinical trials involving iohexol.
• Comparison of subjective sensations (warmth, pain) between iohexol and ionic contrast media.
• Analysis of reported severe adverse events in trials using iohexol.

Main Results:

• Iohexol demonstrated a tendency for less frequent subjective sensations of warmth and pain.
• The intensity of sensations experienced with iohexol was markedly less severe than with ionic media.
• No severe adverse reactions were attributed to the use of iohexol in the studied trials.

Conclusions:

• Iohexol is a well-tolerated non-ionic contrast medium for cerebral angiography.
• Iohexol offers significant advantages in patient comfort compared to ionic contrast media.
• Iohexol can be safely and effectively used in cerebral angiography procedures.