Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adenosine-induced decrease in renin release: dissociation from hemodynamic effects.

L J Arend, A Haramati, C I Thompson

    The American Journal of Physiology
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Detection of influenza A(H3N2) virus in children with suspected mumps during winter 2014/15 in England.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2015
    Same author

    Vaccine effectiveness of 2011/12 trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: evidence of waning intra-seasonal protection.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2013
    Same author

    Evaluation of influenza virus antiviral susceptibility testing in Europe: results from the first external quality assessment exercise.

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2012
    Same author

    Rapid generation of a well-matched vaccine seed from a modern influenza A virus primary isolate without recourse to eggs.

    Vaccine·2010
    Same author

    Reducing de novo donor-specific antibody levels during acute rejection diminishes renal allograft loss.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2009
    Same author

    Proteasome inhibition reduces donor-specific antibody levels.

    Transplantation proceedings·2009
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    Adenosine inhibits renin release independently of its effects on renal blood flow or glomerular filtration. This study demonstrates that adenosine

    Area of Science:

    • Renal Physiology
    • Cardiovascular Pharmacology

    Background:

    • Adenosine influences renal hemodynamics, causing biphasic renal blood flow (RBF) changes and decreasing glomerular filtration rate (GFR).
    • Intrarenal adenosine infusion is known to suppress renin release.

    Purpose of the Study:

    • To investigate whether the adenosine-induced decrease in renin release is dependent on vascular or filtration effects.
    • To dissociate the hemodynamic actions of adenosine from its impact on renin release.

    Main Methods:

    • Adenosine was infused into the kidneys of dogs under conditions designed to alter hemodynamic responses: nonfiltering kidneys, verapamil treatment, and elevated ureteral pressure.
    • Renin release was measured by quantifying angiotensin I (ANG I) levels.

    Main Results:

    Related Experiment Videos

    • In nonfiltering kidneys, adenosine inhibited renin release despite a biphasic RBF response.
    • Verapamil treatment abolished adenosine-induced vasoconstriction and GFR decrease, yet renin release was still inhibited.
    • Elevated ureteral pressure caused sustained vasoconstriction with adenosine, which also inhibited renin release.

    Conclusions:

    • Adenosine-induced inhibition of renin release is independent of its vascular effects (vasoconstriction).
    • Adenosine-induced inhibition of renin release is also independent of its filtration-induced effects (GFR changes).
    • The suppression of renin release by adenosine is not mediated through hemodynamic alterations in the kidney.