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Related Concept Videos

Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma —...

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Related Experiment Video

Updated: Jul 1, 2026

Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications
08:41

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Aztreonam concentrations in human prostatic tissue.

P O Madsen, R Dhruv, L T Friedhoff

    Antimicrobial Agents and Chemotherapy
    |July 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Aztreonam concentrations in prostate tissue were measured after intramuscular injection. Achieved levels exceeded minimum inhibitory concentrations for common chronic prostatitis bacteria.

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    Area of Science:

    • Pharmacology
    • Urology
    • Infectious Diseases

    Background:

    • Chronic prostatitis is often caused by Gram-negative bacteria like Enterobacteriaceae.
    • Effective antibiotic penetration into prostatic tissue is crucial for treatment success.

    Purpose of the Study:

    • To determine aztreonam concentrations in human prostate tissue.
    • To evaluate the potential of aztreonam for treating chronic prostatitis.

    Main Methods:

    • Nine patients received a single 1-g intramuscular dose of aztreonam.
    • Prostate tissue and serum samples were collected via transurethral resection.
    • Aztreonam concentrations were measured using validated assays.

    Main Results:

    • Average aztreonam concentration in prostate tissue was 7.8 µg/g between 50-180 minutes post-dose.
    • The average prostate-to-serum concentration ratio was 0.25.
    • Achieved concentrations were significantly higher than MICs for most Enterobacteriaceae.

    Conclusions:

    • Intramuscular aztreonam achieves therapeutic concentrations in human prostate tissue.
    • Aztreonam demonstrates potential efficacy against bacterial pathogens implicated in chronic prostatitis.