Related Experiment Videos
Effects of bepridil on the resting electrocardiogram
International Journal of Cardiology
|September 1, 1984
Insights
Bepridil hydrochloride, a calcium channel blocker, altered electrocardiogram readings in men with exertional angina. The drug reduced heart rate and prolonged the QT interval, indicating potential cardiac effects.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Exertional angina is a condition characterized by chest pain during physical activity.
- Calcium antagonists are a class of drugs used to treat cardiovascular conditions.
Purpose of the Study:
- To evaluate the electrocardiographic effects of bepridil hydrochloride in patients with exertional angina.
Main Methods:
- The study involved 13 male patients diagnosed with exertional angina.
- Electrocardiograms (ECGs) were monitored after administration of bepridil hydrochloride.
Main Results:
- Bepridil hydrochloride significantly decreased sinus heart rate (P = 0.01).
- The drug markedly increased the QT interval (P < 0.001) and corrected QT (QTc) interval (P < 0.001).
- All patients exhibited T-wave changes on their ECGs.
Conclusions:
- Bepridil hydrochloride demonstrates notable effects on cardiac electrophysiology.
- The observed changes in heart rate and QT intervals warrant consideration in clinical use for exertional angina.
Abstract:
We evaluated the effects of bepridil hydrochloride, a long-acting calcium antagonist, on the electrocardiogram of 13 men with exertional angina. The drug decreased sinus rate (P = 0.01), increased the QT (P less than 0.001) and QTc interval (P less than 0.001), and produced T-wave changes in each patient.