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Related Experiment Videos

Desipramine: an overview.

D S Janowsky, B Byerley

    The Journal of Clinical Psychiatry
    |October 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Desipramine is widely used due to its perceived benefits like faster action and fewer side effects. This review examines evidence supporting these beliefs compared to other antidepressants.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Psychiatry

    Background:

    • Desipramine, a tricyclic antidepressant, has a long history of clinical use.
    • Its widespread adoption is attributed to perceived advantages over other treatments.

    Observation:

    • Clinical beliefs suggest desipramine offers an earlier onset of action.
    • It is also thought to have fewer anticholinergic effects and greater noradrenergic specificity.

    Findings:

    • Recent studies are reviewed to assess these clinical beliefs.
    • Comparison focuses on desipramine's side effects, specificity, and speed of onset versus other tricyclics and newer antidepressants.

    Implications:

    • Understanding desipramine's profile informs clinical antidepressant selection.
    • Evidence-based comparison aids in optimizing treatment strategies for depression.