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Related Experiment Videos

Endocrine dysfunction in children with Crohn's disease.

S K Chong, A Grossman, J A Walker-Smith

    Journal of Pediatric Gastroenterology and Nutrition
    |September 1, 1984
    PubMed
    Summary

    Children with Crohn's disease may experience growth failure due to endocrine issues, including abnormal gonadotropin responses and impaired thyroxine to triiodothyronine conversion. Folate and sedimentation rate can aid in early Crohn's disease screening.

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    Area of Science:

    • Pediatric Endocrinology
    • Gastroenterology
    • Internal Medicine

    Background:

    • Crohn's disease (CD) in children can lead to growth retardation, suggesting potential endocrine involvement.
    • Assessing endocrine function is crucial for managing pediatric CD and its complications.

    Purpose of the Study:

    • To investigate the spectrum of endocrine dysfunction in children with Crohn's disease and growth failure.
    • To identify potential screening markers for pediatric Crohn's disease presenting with growth issues.

    Main Methods:

    • Screened 14 children with Crohn's disease and growth retardation for endocrine abnormalities.
    • Assessed cortisol and growth hormone responses to insulin-induced hypoglycemia.
    • Evaluated gonadotropin response to luteinizing hormone-releasing hormone (LHRH).

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  • Measured serum total thyroxine and total triiodothyronine levels.
  • Monitored serum folate and erythrocyte sedimentation rate (ESR).

    • Main Results:

    • Four children had growth failure; all showed normal cortisol response to hypoglycemia.
    • Abnormal growth hormone response to hypoglycemia was observed in four children.
    • Gonadotropin response to LHRH correlated with pubertal status.
    • Serum total triiodothyronine was low in six patients, normalizing with treatment.
    • Subnormal serum folate and elevated ESR were noted in most patients at diagnosis.

    Conclusions:

    • Children with Crohn's disease exhibit a range of endocrine changes, notably altered gonadotropin responses and impaired thyroxine to triiodothyronine conversion.
    • Growth hormone and cortisol responses may be relatively preserved.
    • Serum folate and ESR are potential screening tools for pediatric Crohn's disease presenting with failure to thrive.