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Related Experiment Videos

Penicillinase-producing Gonococci in Liverpool.

A Percival, J Rowlands, J E Corkill

    Lancet (London, England)
    |December 25, 1976
    PubMed
    Summary

    Penicillinase-producing gonococci emerged in 1976, rendering penicillin treatments ineffective. Spectinomycin showed high success rates, while penicillinase-stable cephalosporins are promising for future treatment of gonorrhea.

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    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Emergence of penicillinase-producing Neisseria gonorrhoeae (PPNG) strains in the UK.
    • PPNG strains acquired TEM-type penicillinase, common in gram-negative bacilli.
    • PPNG isolates rapidly became prevalent, reaching 9% in Liverpool by 1976.

    Purpose of the Study:

    • To assess the clinical impact of PPNG infections.
    • To evaluate the efficacy of different antimicrobial agents against PPNG.
    • To highlight the need for diagnostic tests and alternative treatments.

    Main Methods:

    • Clinical observation of 45 patients infected with PPNG.
    • Treatment efficacy assessment of penicillins, spectinomycin, and tetracyclines.

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  • In vitro susceptibility testing of penicillinase-stable cephalosporins.

    • Main Results:

    • Penicillin treatments failed in all cases of PPNG infection.
    • Spectinomycin achieved a 95% success rate (21/22 patients).
    • Tetracyclines had a 68% success rate (13/19 patients).
    • Penicillinase-stable cephalosporins demonstrated in vitro activity.

    Conclusions:

    • PPNG infections did not show reduced communicability or invasiveness.
    • Standard penicillin treatments are ineffective against PPNG.
    • Spectinomycin is an effective treatment; penicillinase-stable cephalosporins are potential future options.
    • Laboratory detection of PPNG is crucial due to spread within the UK.