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Related Experiment Videos

Fungal splenic abscess.

J D Johnson, M J Raff

    Archives of Internal Medicine
    |October 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Fungal splenic abscesses, often seen in leukemia patients, can be effectively treated with splenectomy and antifungal therapy, leading to good survival rates even with co-existing conditions.

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    Area of Science:

    • Medical Mycology
    • Infectious Diseases
    • Abdominal Imaging

    Background:

    • Fungal splenic abscesses are rare but serious infections.
    • Patients with hematologic malignancies, particularly leukemia, are at increased risk.
    • Diagnosis can be challenging due to non-specific symptoms.

    Observation:

    • Nineteen patients with fungal splenic abscesses were identified.
    • Common predisposing factors included leukemia (16/19), intravenous drug use, Cushing's syndrome, and idiopathic cases.
    • Presenting symptoms included persistent fever (15/19), candidiasis (6/19), abdominal pain (7/19), and splenomegaly (6/19).
    • Radiological findings included pleural effusions, elevated hemidiaphragms, and infiltrates on chest X-ray.
    • Nuclear medicine scans (Technetium-99m sulfur colloid and Gallium-67 citrate) and computed tomography (CT) demonstrated splenic abnormalities.

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    Findings:

    • Candida species were the most common causative agents (15/19), followed by Aspergillus (3/19) and Blastomyces dermatitidis (1/19).
    • Splenectomy was performed in 16 patients, with 12 receiving postoperative antifungal treatment.
    • Fifteen patients survived the infection, irrespective of their underlying conditions or presence of hepatic microabscesses.

    Implications:

    • Early diagnosis and aggressive management, including splenectomy and antifungal therapy, are crucial for improving outcomes in fungal splenic abscesses.
    • Splenic abscesses should be considered in immunocompromised patients presenting with persistent fever and abdominal symptoms.
    • Further research into non-invasive diagnostic methods and optimized antifungal regimens is warranted.