Related Experiment Video

Updated: Aug 12, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

Prostaglandins, related compounds, and the perinatal pulmonary circulation

J B Philips, R K Lyrene

    Clinics in Perinatology
    |October 1, 1984
    PubMed

    Insights

    Prostaglandin-related compounds (PRC) significantly impact the perinatal pulmonary circulation in mammals. This review details PRC

    Area of Science:

    • Perinatal Medicine
    • Cardiovascular Physiology
    • Neonatal Circulation

    Background:

    • Prostaglandins and related compounds play a critical role in the developing and newborn mammalian pulmonary circulation.
    • Understanding these roles is crucial for managing perinatal cardiovascular conditions.

    Purpose of the Study:

    • To review the current knowledge on prostaglandin-related compounds (PRC) in the perinatal pulmonary circulation.
    • To discuss the specific effects of PRC on the ductus arteriosus and systemic circulation in newborns.

    Main Methods:

    • Literature review of existing studies on prostaglandins and perinatal circulation.
    • Synthesis of findings related to PRC in developing and newborn mammals.

    Main Results:

    • PRC are integral to the physiological and pathophysiological processes of the perinatal pulmonary circulation.
    • PRC exert significant influence on the patency and closure of the ductus arteriosus.
    • PRC also affect the overall systemic circulation in the perinatal period.

    Conclusions:

    • Prostaglandin-related compounds are key regulators of cardiovascular adaptation at birth.
    • Further research into PRC mechanisms can inform therapeutic strategies for neonatal circulatory disorders.

    More Related Videos

    Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets08:08

    Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

    Published on: May 11, 2015

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

    Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

    Published on: October 31, 2025

    Related Concept Videos

    Fetal Circulation01:14

    Fetal Circulation

    Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
    Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
    Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

    Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

    Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
    These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
    Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents01:20

    Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

    The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
    Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
    Pulmonary Cycle: Exhalation01:17

    Pulmonary Cycle: Exhalation

    In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
    Acute Inflammation III: Local and Systemic Effects01:25

    Acute Inflammation III: Local and Systemic Effects

    Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
    Pulmonary Embolism I: Introduction01:19

    Pulmonary Embolism I: Introduction

    A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...