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Related Experiment Videos

Desquamative gingivitis and extragingival collapsed bulla.

J L Jensen, R W Correll, W B Wescott

    Journal of the American Dental Association (1939)
    |November 1, 1984
    PubMed
    Summary

    Mucous membrane pemphigoid is a rare, chronic disease affecting oral and ocular mucosa, potentially causing blindness. Treatment involves corticoid hormones, dapsone, and periodontal therapy with variable success.

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    CJEM·2016

    Area of Science:

    • Oral Medicine
    • Ophthalmology
    • Dermatology

    Background:

    • Mucous membrane pemphigoid (MMP) is a rare, chronic autoimmune blistering disease.
    • It primarily targets the mucous membranes, particularly the oral and ocular mucosa.
    • Skin and other mucous membranes can also be affected, though less commonly.

    Observation:

    • Oral lesions in MMP often manifest as desquamative gingivitis, ulcers, and collapsed vesicles or bullae.
    • Ocular involvement is a significant concern, with the potential to lead to severe vision impairment and blindness.
    • The disease's chronic and scarring nature necessitates ongoing management.

    Findings:

    • MMP presents a diagnostic challenge due to its variable presentation.
    • Histopathological examination and direct immunofluorescence are crucial for diagnosis.
    • The disease course is typically chronic and can lead to significant morbidity.

    Implications:

    • Early diagnosis and prompt treatment are vital to prevent irreversible damage, especially in the eyes.
    • Current therapeutic options, including corticoid hormones, dapsone, and periodontal therapy, offer variable success rates.
    • Further research is needed to develop more effective and targeted treatments for mucous membrane pemphigoid.

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