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Related Experiment Videos

Migraine prevention with timolol. A double-blind crossover study.

S Stellar, S P Ahrens, A R Meibohm

    JAMA
    |November 9, 1984
    PubMed
    Summary

    Timolol maleate, a beta-blocker, effectively reduces migraine headache frequency and improves patient outcomes. This prophylactic treatment is safe and well-tolerated for frequent migraine sufferers.

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    Area of Science:

    • Neurology
    • Pharmacology

    Background:

    • Migraine headaches are a prevalent neurological condition affecting a significant portion of the population.
    • Prophylactic treatments are crucial for managing frequent migraine episodes and improving quality of life.

    Purpose of the Study:

    • To evaluate the efficacy and safety of timolol maleate as a prophylactic treatment for migraine headaches.
    • To compare timolol maleate against a placebo in a double-blind crossover study.

    Main Methods:

    • A 20-week double-blind crossover study involving 107 patients with migraine headaches.
    • Patients received either timolol maleate (20-30 mg/day) or a matching placebo.
    • Outcomes measured included headache frequency, 50% reduction in headache frequency, global response, and patient preference.

    Main Results:

    • Timolol maleate demonstrated significant improvements compared to placebo in reducing headache frequency.
    • A higher percentage of patients on timolol achieved a 50% reduction in headache frequency and reported a positive global response (65% vs. 40%).
    • Headache severity and duration remained unchanged; few side effects were reported for both treatments.

    Conclusions:

    • Timolol maleate is a safe and effective prophylactic treatment for patients experiencing frequent migraine headaches.
    • The study supports the use of beta-blockers, specifically timolol, in migraine management.

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