High-frequency ventilation: a review
Related Experiment Video
Updated: Oct 9, 2026

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
Published on: April 29, 2011
Abstract:
As a new mode of assisted ventilation, high-frequency ventilation (HFV) embodies several types of devices, all of which employ tidal volumes much smaller and frequencies much greater than conventional mechanical ventilation (CMV). Due to the smaller swings of airway pressure during HFV, it is thought that some of the drawbacks of CMV may be overcome. Besides the obvious clinical implications, considerable interest has been generated concerning the physiological effects of HFV. In this review, the effects of HFV on gas exchange, lung mechanics, mucociliary transport, cardiovascular function and control of breathing will be examined. Although the role of HFV in the management of different lung diseases is still unclear, it has proved to be both a strong stimulus and a useful tool in the study of physiology.
More Related Videos
Related Concept Videos
Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

