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Neurogenic pulmonary edema.

G L Colice, M A Matthay, E Bass

    The American Review of Respiratory Disease
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Neurogenic pulmonary edema (NPE) occurs after central nervous system (CNS) insults. Pathophysiology involves increased lung vascular permeability or hydrostatic pressure, requiring varied treatments.

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    Area of Science:

    • Neurology
    • Pulmonology
    • Critical Care Medicine

    Background:

    • Central nervous system (CNS) insults can trigger acute pulmonary edema, a condition known as neurogenic pulmonary edema (NPE).
    • The exact pathophysiological mechanisms underlying NPE remain incompletely understood.
    • Existing theories suggest either increased pulmonary vascular permeability or hydrostatic pressure changes contribute to NPE development.

    Purpose of the Study:

    • To explore the pathophysiologic mechanisms of neurogenic pulmonary edema (NPE).
    • To differentiate between hydrostatic and permeability-based causes of NPE.
    • To inform potential treatment strategies for NPE based on its underlying cause.

    Main Methods:

    • Review of existing clinical and experimental studies on NPE.

    Related Experiment Videos

  • Analysis of NPE pathogenesis based on Starling's equation and hydrostatic-permeability principles.
  • Evaluation of the 'blast theory' and alternative hypotheses for NPE development.

    • Main Results:

    • Experimental models confirm CNS insults can induce pulmonary edema.
    • NPE may result from increased pulmonary endothelial permeability, hydrostatic pressure changes, or a combination.
    • Recent evidence suggests CNS disorders can cause permeability defects independently of vascular insults.

    Conclusions:

    • Neurogenic pulmonary edema (NPE) pathogenesis is complex and may involve either permeability abnormalities or hydrostatic insults.
    • NPE presentation and required treatments can vary significantly depending on the underlying mechanism.
    • Further research is needed to elucidate the specific CNS sites and neural mechanisms mediating NPE.