Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic catecholaminergic effects on prolactin release in vitro.

W C Friend, G M Brown, S Kirpalani

    Canadian Journal of Physiology and Pharmacology
    |April 1, 1978
    PubMed
    Summary

    Hypothalamic dopamine and norepinephrine directly inhibit prolactin release. The hypothalamus uses dopamine, not norepinephrine, to control prolactin secretion.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Suicidal ideation in a random community sample: attributable risk due to depression and psychosocial and traumatic events.

    The Australian and New Zealand journal of psychiatry·2001
    Same author

    Index of suspicion. Case 3. Diagnosis: septic arthritis.

    Pediatrics in review·2001
    Same author

    The European Society of Gastrointestinal Endoscopy (ESGE): check list for the purchase of washer-disinfectors for flexible endoscopes. ESGE Guideline Committee.

    Endoscopy·2000
    Same author

    Why nurses need to advocate for Medicare by opposing contracting out.

    Alberta RN·2000
    Same author

    Glioblastoma induction after radiosurgery for meningioma.

    Lancet (London, England)·2000
    Same author

    The low prevalence of shiga-toxin production among sorbitol non-fermenting Escherichia coli urinary tract isolates does not warrant routine screening.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000

    Area of Science:

    • Neuroendocrinology
    • Hormone Regulation
    • Pituitary Gland Function

    Background:

    • Prolactin is a key hormone regulated by the hypothalamus.
    • Catecholamines are neurotransmitters with known endocrine effects.
    • Understanding hypothalamic control over prolactin is crucial for reproductive health.

    Purpose of the Study:

    • To investigate the in vitro effects of hypothalamic catecholamines on prolactin release.
    • To determine the direct and indirect roles of dopamine and norepinephrine in prolactin inhibition.
    • To identify the specific hypothalamic neurotransmitters involved in prolactin regulation.

    Main Methods:

    • In vitro studies using isolated hemipituitary and hemipituitary-hypothalamus co-cultures.
    • Administration of various catecholamines and their precursors.
    • Measurement of prolactin release in response to different stimuli.

    Main Results:

    • Dopamine and norepinephrine demonstrated long-lasting inhibition of prolactin release.
    • Epinephrine also inhibited prolactin release, while L-dihydroxyphenylalanine (L-dopa) showed inhibition only with hypothalamic presence.
    • Serotonin, TRH, LH-RH, and somatostatin did not affect prolactin release.

    Conclusions:

    • Dopamine and norepinephrine directly inhibit pituitary prolactin release.
    • The hypothalamic mechanism for inhibiting prolactin secretion primarily involves dopamine, not norepinephrine.
    • These findings clarify the neurochemical pathways regulating prolactin.

    Related Experiment Videos