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Related Experiment Videos

Disopyramide phosphate: is it just another quinidine.

T Kus, B I Sasyniuk

    Canadian Journal of Physiology and Pharmacology
    |April 1, 1978
    PubMed
    Summary

    Disopyramide and quinidine affect cardiac action potential duration similarly, while disopyramide and lidocaine both reduce action potential upstroke velocity. These antiarrhythmic drugs exhibit complex cardiac electrophysiology effects.

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    Area of Science:

    • Cardiac Electrophysiology
    • Pharmacology

    Background:

    • Antiarrhythmic drugs are crucial for managing cardiac arrhythmias.
    • Understanding the specific electrophysiological effects of drugs like disopyramide, quinidine, and lidocaine is essential for optimizing their clinical use.

    Purpose of the Study:

    • To compare the effects of disopyramide, quinidine, and lidocaine on cardiac action potential characteristics.
    • To investigate the steady-state relationship between membrane potential and action potential upstroke velocity under these drug treatments.

    Main Methods:

    • Experiments were conducted on normal Purkinje fibers with stable impalement for over 7 hours.
    • Action potential characteristics and steady-state voltage-dependent properties were measured in the presence of therapeutic concentrations of disopyramide, quinidine, and lidocaine.

    Main Results:

    • All drugs depressed steady-state upstroke velocity, with quinidine > disopyramide > lidocaine.
    • Lidocaine and disopyramide shifted the normalized steady-state curve to more negative potentials, indicating greater depression at lower potentials.
    • Lidocaine abbreviated repolarization; disopyramide and quinidine shortened the plateau and lengthened the terminal repolarization phase.

    Conclusions:

    • Disopyramide's effects on upstroke velocity resemble lidocaine's.
    • Disopyramide's effects on action potential duration are similar to quinidine's.
    • The electrophysiological actions of disopyramide are complex and multifaceted.

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