Transnasal transsphenoidal approach to the sella

Area of Science:

• Neurosurgery
• Endocrinology

Background:

• The transnasal transsphenoidal approach has evolved significantly with medical and technological advancements.
• Historically used for pituitary adenoma excision, its current primary application is pituitary ablation for hormonally dependent diseases.

Purpose of the Study:

• To evaluate the efficacy and safety of the transnasal transsphenoidal approach for pituitary ablation.
• To demonstrate the technique's ability to provide excellent exposure of intrasellar contents.

Main Methods:

• A retrospective study of 55 patients who underwent the transnasal transsphenoidal procedure between 1970 and 1975.
• Utilized a microscopic technique with specific instrument modifications.

Main Results:

• The microscopic transnasal transsphenoidal approach provided excellent exposure and visualization of intrasellar contents.
• The procedure was technically straightforward, associated with minimal morbidity and mortality.

Conclusions:

• The transnasal transsphenoidal approach is a safe and effective method for pituitary ablation in hormonally dependent diseases.
• Instrument modifications enhance the technique's utility and safety profile.