The erythrocyte insulin receptor response to either feeding or a short fast

We have examined insulin binding to the erythrocyte insulin receptor in normal males following a short fast and a test meal or glucose load. The binding increased following the fast. This increase appeared to be due to increased receptor affinity. Following the meal or glucose load no change in insulin binding was detected. These results are compared with conflicting data in the literature and possible technical explanations for the discrepancies are explored.