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Plasma cell neoplasm involving the thyroid.

K Shimaoka, S Gailani, Y Tsukada

    Cancer
    |March 1, 1978
    PubMed
    Summary
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    Plasma cell neoplasms rarely involve the thyroid gland. A review identified 4 cases of thyroid plasma cell neoplasm, presenting as localized or generalized disease, or found incidentally at autopsy.

    Area of Science:

    • Endocrinology
    • Oncology
    • Pathology

    Background:

    • Plasma cell neoplasms are a group of malignant plasma cell disorders.
    • Extramedullary involvement by plasma cell neoplasms is uncommon.
    • Thyroid gland involvement by plasma cell neoplasms is exceptionally rare.

    Observation:

    • A retrospective review of 248 cases of plasma cell neoplasms was conducted.
    • Four cases with pathological evidence of thyroid plasma cell neoplasm were identified.
    • These four cases represented a heterogeneous group regarding disease presentation and extent.

    Findings:

    • Thyroid involvement was clinically recognized as extramedullary disease in one patient.
    • Two patients presented with thyroid involvement as part of generalized plasma cell neoplasm.

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  • In one patient with generalized disease, thyroid involvement was an autopsy finding.

    • Implications:

    • This study highlights the rare occurrence of plasma cell neoplasms in the thyroid.
    • Understanding the varied presentations is crucial for accurate diagnosis and management.
    • Further research may elucidate the specific mechanisms and risk factors for thyroid involvement.