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Related Experiment Videos

Implications from SEER data on breast cancer management.

C R Smart, M H Myers, L A Gloeckler

    Cancer
    |March 1, 1978
    PubMed
    Summary

    This study analyzed 8,587 breast cancer cases from 1975. Even without palpable lymph nodes, over a third of invasive breast cancers showed positive axillary lymph node involvement.

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    Area of Science:

    • Oncology
    • Epidemiology
    • Cancer Research

    Background:

    • Breast cancer diagnosis and staging are critical for treatment planning.
    • Axillary lymph node status is a key prognostic indicator in breast cancer.
    • Early detection and accurate staging can improve patient outcomes.

    Purpose of the Study:

    • To analyze the characteristics of breast cancer cases diagnosed in 1975.
    • To determine the prevalence of noninvasive breast cancer in the study cohort.
    • To assess the rate of axillary lymph node positivity in invasive breast cancers, particularly in cases with no palpable nodes.

    Main Methods:

    • Utilized data from the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) program.
    • Analyzed 8,587 breast cancer cases diagnosed in the year 1975.
    • Examined tumor size and axillary lymph node status for invasive breast cancer cases.

    Main Results:

    • 5.3% of the analyzed breast cancer cases were classified as noninvasive.
    • For invasive breast cancers smaller than 0.5 cm, 17.2% had positive axillary lymph nodes.
    • In cases where physicians recorded no palpable axillary lymph nodes, 34.5% were found to be positive for cancer spread.

    Conclusions:

    • A significant proportion of invasive breast cancers, even small ones, involve the axillary lymph nodes.
    • The absence of palpable axillary lymph nodes does not rule out lymph node metastasis.
    • These findings highlight the importance of thorough staging in breast cancer management.

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