The analysis of total and form-variable tin in various media

Methods for both total and form-variable tin analysis in biological media are reviewed. While total tin analysis was common in the past, and in some cases still is, better understanding of the toxicology and toxicokinetics of organotins in biological systems requires knowledge of specific tin forms present. Both chromatographic and non-chromatographic methods for chemical speciation of organotins in various media have been described, the former appearing to offer the most promising approaches. High performance liquid chromatography (HPLC) in tandem with tin-specific metal detection presently appears to offer the most promise.