67Ga and 59Fe uptakes by cultured human lymphoblasts and lymphocytes

Studies with spontaneously proliferating human lymphoblastoid cells have shown that cellular uptake of both 67Ga and 59Fe3+ (as citrates) become appreciably increased with small additions of purified human transferrin to the cultures. In many respects, their uptake responses were broadly similar to those previously reported for cultured mouse lymphoid tumor cells. Studies were also undertaken with cultured human lymphocytes, but transferrin promotion of tracer uptakes could not be detected for these cells. In addition, cellular uptakes for phytochemagglutinin-stimulated cultures were not significantly increased over their unstimulated controls.