[High-dose thalamonal-rohypnol for premedication. A randomized double-blind study].

Area of Science:

• Anesthesiology
• Pharmacology
• Psychology

Background:

• Premedication is crucial for managing patient anxiety and physiological stress before surgery.
• Evaluating the efficacy and safety of different anesthetic agents for premedication is essential.

Purpose of the Study:

• To compare the efficacy of flunitrazepam versus Innovar (fentanyl and droperidol) for intramuscular premedication.
• To assess the impact of these agents on psychological and physiological stress parameters.

Main Methods:

• A comparative study involving patients receiving either flunitrazepam or Innovar for premedication.
• Measurement of psychological (anxiety) and physiological (blood pressure, heart rate, cortisol) stress markers.
• Documentation of side effects and post-operative patient satisfaction.

Main Results:

• Flunitrazepam significantly reduced anxiety, while Innovar did not.
• Innovar led to a significant increase in perceived weakness and two patients refused surgery due to panic.
• Flunitrazepam showed slight advantages in managing physiological stress parameters.

Conclusions:

• Flunitrazepam is a more effective premedication agent than Innovar for reducing anxiety and improving patient experience.
• Innovar, even at higher doses, is not recommended for premedication due to adverse psychological effects and lack of anxiolysis.