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Related Experiment Videos

Oral rehydration solution without bicarbonate.

M R Islam, S M Ahmed

    Archives of Disease in Childhood
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Oral rehydration solution without bicarbonate effectively treats dehydration and acidosis in children with acute watery diarrhea. While initial acidosis correction is slower, it becomes comparable to WHO oral rehydration solution within 48 hours.

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    Area of Science:

    • Pediatrics
    • Gastroenterology
    • Clinical Trials

    Background:

    • Acute watery diarrhea in children often leads to dehydration and acidosis.
    • Standard oral rehydration solution (ORS) typically includes bicarbonate to correct acidosis.
    • The efficacy of ORS without bicarbonate requires further investigation.

    Purpose of the Study:

    • To compare the efficacy of oral rehydration solution without bicarbonate versus the World Health Organization (WHO) ORS in treating dehydration and acidosis in young children.
    • To assess treatment success rates and the speed of acidosis correction.

    Main Methods:

    • A double-blind, randomized clinical trial involving 98 young children with acute watery diarrhea.
    • Children presented with varying degrees of dehydration and acidosis.

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  • Treatment groups received either ORS without bicarbonate or WHO ORS.

    • Main Results:

    • The non-bicarbonate ORS group showed successful treatment in all but three children, attributed to persistent vomiting and severe diarrhea.
    • Acidosis correction was slower in the non-bicarbonate group during the first 24 hours (P < 0.001).
    • By 48 hours, acidosis was corrected in both groups, with comparable serum bicarbonate levels (P > 0.05).

    Conclusions:

    • Oral rehydration solution without bicarbonate is a viable alternative when the complete WHO formula is unavailable.
    • Treatment failures may occur due to persistent vomiting and severe diarrhea.
    • While initial acidosis correction is slower, non-bicarbonate ORS effectively manages dehydration and acidosis in children.