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Related Experiment Videos

Indomethacin sustained-release?

J A Green

    Drug Intelligence & Clinical Pharmacy
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    New sustained-release drug formulations require specific properties for efficacy. Indomethacin

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    Area of Science:

    • Pharmacokinetics and Drug Formulation
    • Clinical Pharmacology

    Background:

    • Many older drugs are being reformulated into sustained-release (SR) preparations.
    • However, not all SR formulations have a strong scientific basis for their development.

    Purpose of the Study:

    • To evaluate the scientific rationale and clinical justification for marketing sustained-release indomethacin.
    • To determine if SR indomethacin offers advantages over conventional formulations.

    Main Methods:

    • Literature review examining indomethacin's pharmacokinetic properties.
    • Assessment of indomethacin against criteria for successful SR formulation development.

    Main Results:

    • Indomethacin does not meet the key criteria for successful SR formulation.

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  • Specifically, it lacks a clear concentration/response relationship and has a long plasma elimination half-life.

    • Conclusions:

    • The marketing of sustained-release indomethacin is not scientifically justified.
    • Clinical studies have not demonstrated any significant advantages of the SR formulation over the conventional form.