A model of DSB-repair kinetics

A model of repair kinetics of DSB based on a step-by-step removal of individual double-strand breaks inside an autonomous repair unit is proposed and compared with the alternative model commonly used in modelling repair kinetics, which is based on an assumption of stochastic removal of cellular lesions. The former model seems to be preferred by the recently published experimental data displaying the time decrease of average DSB number per cell in irradiated Saccharomyces cerevisiae (strain 211 B) held in non-growth conditions.