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Silver deposition in mouse glomeruli.

W A Day, J S Hunt, A R McGiven

    Pathology
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Mice drinking silver nitrate developed silver granules in kidney glomeruli within 12 days. These deposits persisted long after silver exposure ceased, indicating potential long-term effects of silver accumulation.

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    Area of Science:

    • Nephrology
    • Toxicology
    • Materials Science

    Background:

    • Silver compounds are used in various applications.
    • Understanding the biological fate and deposition of silver is crucial.

    Purpose of the Study:

    • To investigate the deposition and persistence of silver in mouse kidneys following oral administration of silver nitrate.

    Main Methods:

    • Mice were administered 6 mM silver nitrate in drinking water.
    • Kidney tissues were examined using electron microscopy at various time points.
    • Silver deposition was assessed in the glomerular basement membrane, mesangium, and other renal structures.

    Main Results:

    • Silver granules were detected in the glomerular basement membrane after 12 days of silver nitrate administration.

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  • Larger silver aggregates formed in the basement membrane and mesangium with extended ingestion (14 weeks).
  • Deposited silver remained significantly unchanged for 21 weeks after cessation of silver nitrate intake.

    • Conclusions:

    • Oral silver nitrate administration leads to significant silver deposition in mouse renal glomeruli.
    • These silver deposits exhibit long-term persistence in kidney tissues.
    • The findings highlight the potential for bioaccumulation of silver in renal structures.