Rapid estimation of serum theophylline clearance in children with acute asthma

Serum theophylline clearance was estimated prior to reaching steady state in 29 asthmatic children, aged 1-14 years, using methods described by Chiou et al. and Vozeh et al. Comparison of the estimated clearance by the Vozeh method (0.094 +/- 0.005 L/kg/h) did not differ significantly from that estimated by the Chiou method (0.094 +/- 0.005 L/kg/h). Neither estimate of serum theophylline clearance differed significantly from the calculated clearance at steady state (0.092 +/- 0.006 L/kg/h). Linear correlations between predicted and observed serum theophylline clearances were found for both the Chiou (p = 0.002, r = 0.54) and Vozeh (p = 0.02, r = 0.49) methods. Estimates of the steady-state serum theophylline concentrations by the Vozeh method (10.32 +/- 0.56 mg/L) and the Chiou method (10.28 +/- 0.52 mg/L) did not differ significantly from each other or from the observed steady-state serum theophylline concentration (10.54 +/- 0.48 mg/L). A linear correlation between predicted and observed serum theophylline concentrations was found for both the Chiou (p = 0.02, r = 0.43) and Vozeh (p = 0.001, r = 0.57) methods. These results suggest that either method of estimating serum theophylline clearance can be used to rapidly individualize therapy in children with acute asthma.